The variant translocation of ABL1 Gene t(2;9)(q21;q34) in a childhood T-cell acute lymphoblastic leukemia

Karkucak, M.; Yakut, T.; Baytan, B.; Gulten, T.; Gunes, A.

doi:10.4149/bll_2012_004

The variant translocation of ABL1 Gene t(2;9)(q21;q34) in a childhood T-cell acute lymphoblastic leukemia

Atıf İçin Kopyala

Karkucak M., Yakut T., Baytan B., Gulten T., Gunes A. M.

BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY, cilt.113, sa.1, ss.19-20, 2012 (SCI-Expanded)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 113 Sayı: 1
Basım Tarihi: 2012
Doi Numarası: 10.4149/bll_2012_004
Dergi Adı: BRATISLAVA MEDICAL JOURNAL-BRATISLAVSKE LEKARSKE LISTY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.19-20
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

We present the case of the childhood ALL that was identified by the translocation of the ABL1 gene to the q21 band of chromosome 2 without t(9;22)(q34;q11) translocation. The observation of a poor clinical course of the case may contribute to explanation of the action of t(9;22)(q34;q11) translocation, of which poor prognostic action is known on ALL's, in terms of ABL1 gene, independent of the BCR gene. On the other hand, the prognostic significance of this variant ABL1 translocation detection, which is very rarely observed, will cast a light on future cases (Tab. 1, Fig. 1, Ref. 11). Full Text in free PDF www.bmj.sk.