Akademik Veri Yönetim Sistemi
VI. Uluslararası Türk Dünyası Fen Bilimleri ve Mühendislik Kongresi , Baku, Azerbaycan, 19 - 21 Aralık 2024, ss.115
Petrosedum sediforme (P. sediforme), a member of the Crassulaceae family, is one of the 33 sedum species growing in Turkey. This plant, which is known as “damkorugu” and grows in rocky areas, is also called golden herb because of its golden yellow flowers. The plant, which is preferred in traditional medicine for its anti-inflammatory, hemostatic and antifungal properties, is suggested to be used in nutritional supplements as a functional food ingredient. In the contemporary era, there is a gradual increase in health problems caused by increasing environmental problems and radiological exposure. In studies, it is stated that plants may have preventive properties against various diseases due to the antioxidant components they contain. In this study, ultrasonic-assisted extraction was carried out with two different solvent mixtures, glycerol-water (50% v/v) and methanol-water (50% v/v), using flowers, buds, leaves and stems of the damkorugu. Following extractions, the antioxidant capacity was determined using spectroscopic methods the ABTS, CUPRAC and FRAP and the total phenolic content was determined by Folin Ciocalteu method. High Performance Liquid Chromatography (HPLC-DAD) was used for the quantitative determination of phenolic compounds in each extract. The main phenolic components identified in the extracts were resveratrol, kaempferol 3-β-D-glucoside, quercitrin and hyperoside. The methanol-water extract of the damkorugu flower was determined as the extract with the highest antioxidant properties. The cytotoxic effect of this extract was determined on MCF-7 and MDA-MB-231 cell lines using Sulforhodamine B test. The extract significantly inhibited both cell lines depending on the concentration.