Growth of Staphylococcus aureus, Candida albicans, Escherichia coli and Pseudomonas aeruginosa in Propofol, Thiopental and a 1:1 Propofol-Thiopental Mixture

TOPAL A., BİLGİN H., ÖZAKIN C., Gedikoglu S., GÜL SATAR N. Y.

JOURNAL OF ANIMAL AND VETERINARY ADVANCES, cilt.9, sa.10, ss.1432-1435, 2010 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 9 Sayı: 10
  • Basım Tarihi: 2010
  • Doi Numarası: 10.3923/javaa.2010.1432.1435
  • Dergi Adı: JOURNAL OF ANIMAL AND VETERINARY ADVANCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1432-1435
  • Anahtar Kelimeler: Intravenous anesthetics, propofol, thiopental, mixture, bacteria, growth rate, BACTERIAL-CONTAMINATION, MICROORGANISMS
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Extrinsic contamination of propofol is thought to be a source of postoperative sepsis. Researchers studied growth of Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and Candida albicans in propofol, thiopental and in a 1:1 propofol-thiopental mixture. All microorganisms were taken from standard stock cultures. Half of the samples were incubated at 20 degrees C and the rest were stored at 4 degrees C for 120 h. Growth of microorganisms in each solution was compared by counting the number of the Colony-Forming Units (CFUs) at 0, 3, 6, 24, 72 and 120 h. Propofol supported the growth of all four microorganims at both temperatures. In contrast, thiopental and the 1:1 propofol-thiopental mixture exhibited markedly bactericidal properties on E. coli, C. albicans and P. aeruginosa and bacteriostatic effect on S. aureus.