Efficacy of losartan in patients with primary focal segmental glomerulosclerosis resistant to immunosuppressive treatment

Usta M., Ersoy A., Dilek K., Ozdemir B., Yavuz M., Gullulu M., ...More

JOURNAL OF INTERNAL MEDICINE, vol.253, no.3, pp.329-334, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 253 Issue: 3
  • Publication Date: 2003
  • Doi Number: 10.1046/j.1365-2796.2003.01071.x
  • Journal Name: JOURNAL OF INTERNAL MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.329-334
  • Keywords: angiotensin receptor blockade, focal seg- mental glomerulosclerosis, losartan, proteinuria, treatment resistant, CONVERTING-ENZYME-INHIBITION, RENIN-ANGIOTENSIN SYSTEM, RENAL-FUNCTION, GLOMERULAR SCLEROSIS, NEPHROPATHY, PROTEINURIA, ABLATION, RAMIPRIL, DECLINE, THERAPY
  • Bursa Uludag University Affiliated: Yes

Abstract

Objectives. Angiotensin II may play an important role in the progression of renal disease. Currently, angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor antagonists are commonly used for renoprotection. To our knowledge, there is no study investigating this effect of angiotensin II receptor antagonists in patients with primary focal segmental glomerulosclerosis (FSGS) in the literature. The aim of this study was to evaluate the effects of losartan on proteinuria and renal function in patients with FSGS refractory to immunosuppressive treatment.