The efficacy of curcumin on PDGF expression and NF-kappa B pathway: TNBS-induced colitis


Altinel Y., Yalcin S., Ercan G., Yavuz E., Ercetin C., Gulcicek O. B., ...More

ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY, vol.26, no.5, pp.663-670, 2020 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 26 Issue: 5
  • Publication Date: 2020
  • Doi Number: 10.14744/tjtes.2019.45570
  • Journal Name: ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CINAHL, EMBASE, MEDLINE, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.663-670
  • Keywords: Anti-inflammatory, anti-oxidant, colitis, curcumin, NF-kappaB, SMOOTH-MUSCLE-CELLS, ULCERATIVE-COLITIS, MODEL, RATS, INNERVATION, THERAPY, EXTRACT, GROWTH
  • Bursa Uludag University Affiliated: Yes

Abstract

BACKGROUND: Curcumin is an antioxidant and anti-inflammatory molecule known to be a potent inhibitor of nuclear factor kappa B (NF-kappa B). In this study, we aimed to investigate the therapeutic effects of curcumin on colitis induced by a 2,4,6-trinitrobenzene sulfonic acid (TNBS).