Proteomics Analysis of CA1 Region of the Hippocampus in Pre-, Progression and Pathological Stages in a Mouse Model of the Alzheimer's Disease

Gurel B., CANSEV M., Koc C., ÖCALAN B., ÇAKIR A., Aydin S., ...More

CURRENT ALZHEIMER RESEARCH, vol.16, no.7, pp.613-621, 2019 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 7
  • Publication Date: 2019
  • Doi Number: 10.2174/1567205016666190730155926
  • Journal Name: CURRENT ALZHEIMER RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.613-621
  • Keywords: Alzheimer's disease, CA1, proteomics, 5XFAD, A beta plaques, cerebral cortex, MEMORY IMPAIRMENT, OXIDATIVE STRESS, BRAIN, DYSREGULATION, EXPRESSION, 5XFAD, IRON, NEUROPLASTICITY, IDENTIFICATION, PATHOGENESIS
  • Bursa Uludag University Affiliated: Yes

Abstract

Background: CA1 subregion of the hippocampal formation is one of the primarily affected structures in AD, yet not much is known about proteome alterations in the extracellular milieu of this region. Objective: In this study, we aimed to identify the protein expression alterations throughout the pre-pathological, progression and pathological stages of AD mouse model.