Proteomics Analysis of CA1 Region of the Hippocampus in Pre-, Progression and Pathological Stages in a Mouse Model of the Alzheimer's Disease

Gurel B., CANSEV M., Koc C., ÖCALAN B., ÇAKIR A., Aydin S., ...Daha Fazla

CURRENT ALZHEIMER RESEARCH, cilt.16, sa.7, ss.613-621, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 16 Sayı: 7
  • Basım Tarihi: 2019
  • Doi Numarası: 10.2174/1567205016666190730155926
  • Dergi Adı: CURRENT ALZHEIMER RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.613-621
  • Anahtar Kelimeler: Alzheimer's disease, CA1, proteomics, 5XFAD, A beta plaques, cerebral cortex, MEMORY IMPAIRMENT, OXIDATIVE STRESS, BRAIN, DYSREGULATION, EXPRESSION, 5XFAD, IRON, NEUROPLASTICITY, IDENTIFICATION, PATHOGENESIS
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Background: CA1 subregion of the hippocampal formation is one of the primarily affected structures in AD, yet not much is known about proteome alterations in the extracellular milieu of this region. Objective: In this study, we aimed to identify the protein expression alterations throughout the pre-pathological, progression and pathological stages of AD mouse model.