Evaluation of an alternative treatment protocol by aglepristone to induce parturition in ewes with an experimental model of early pregnancy toxemia


ÖZALP R. G. , Yavuz A., Seker I., Udum-Kucuksen D. , Risvanli A., Korlu Y.

THERIOGENOLOGY, vol.116, pp.112-118, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 116
  • Publication Date: 2018
  • Doi Number: 10.1016/j.theriogenology.2018.04.032
  • Title of Journal : THERIOGENOLOGY
  • Page Numbers: pp.112-118
  • Keywords: Ewe, Parturition induction, Pregnancy toxemia, Aglepristone, Dexamethasone, PROGESTERONE-RECEPTOR BLOCKER, SPONGY DEGENERATION, PLASMA-GLUCOSE, DEXAMETHASONE, SHEEP, LAMBS, PROFILES, METABOLISM, COLOSTRUM, ANIMALS

Abstract

A new protocol with aglepristone to induce parturition in ewes with pregnancy toxemia has been reported in the present manuscript. Four experimental groups were defined: Group AG5 (n = 10), Group DEX (n = 10), Group NC (n = 5) and Group PT (n = 5) in which ewes were injected twice with 10 mg/kg of aglepristone and 5 ml dexamethasone in first two groups, respectively; whereas negative control and pregnancy toxemia groups received no treatment for parturition induction. Different clinical parameters associated with parturition in ewes and their newborns were investigated. Blood hematology and biochemical measurements were carried out both in ewes and lambs. Blood pH values of lambs were recorded during the study. The injection time-lambing time, injection time-vaginal discharge intervals, placental expulsion periods, placental weight and vaginal delivery interval between lambs, hematological and biochemical results were not statistically different among the groups (p > 0,05). Increased NEFA and 3-HBA concentrations accompanied the disease and all ewes in AG, DEX and PT Groups developed clinical pregnancy toxemia (NEFA; P = 0,009) and beta-HBA; (P = 0,039). The differences in rectal body temperature of lambs were not significant (p > 0,05), whereas birth weight was found statistically significant among groups (p <0,05). Blood pH, biochemical and hematologic measurements of lambs had also significant differences depending on different time points. Parturition pathology by means of incomplete cervical dilatation was severely observed in DEX Group.