Determination of phytochemical contents by LC/ QTOF/MS and evaluation of in-vitro biological activities of 2 Peltigera lichens from Bursa

Tüzün B. S., Karadağ B. T., ORAN S., ÖZTÜRK Ş., YILMAZ F. F., Fafal T., ...Daha Fazla

Anais da Academia Brasileira de Ciencias, cilt.96, sa.2, 2024 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 96 Sayı: 2
  • Basım Tarihi: 2024
  • Doi Numarası: 10.1590/0001-3765202420230657
  • Dergi Adı: Anais da Academia Brasileira de Ciencias
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Aerospace Database, Animal Behavior Abstracts, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, CAB Abstracts, Communication Abstracts, EMBASE, INSPEC, Metadex, Veterinary Science Database, zbMATH, Directory of Open Access Journals, Civil Engineering Abstracts
  • Anahtar Kelimeler: Antioxidant, LC/QTOF/MS, Lichen phenolics, Peltigera elisabethae Gyeln, Peltigera praetextata (Flörke ex Sommerf.), Tyrosinase inhibitor
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Lichens are symbiotic associations of algae and fungi. They are edible as food and have been used in traditional medicine for years. It is aimed to screen Peltigera praetextata (Flörke ex Sommerf.) Zopfand and Peltigera elisabethae Gyeln. phytochemically by LC/QTOF/MS and according to the constituents to evaluate the antioxidant, tyrosinase inhibitory, and antibacterial activities. In total 54 of metabolites detected by LC/QTOF/MS were common in both species. According to LC/QTOF/MS scanning results, alkaloids, iridoid glycosides, phenolics, cyanogenetic glycosides, and terpenic structures were detected. DPPH, ABTS, superoxide radical scavenging activities, and metal chelating capacity IC50 values were 84.55, 9.349; 51.27, 9.127; 95.01, 58.65 and 20.57, 70.08 µg/mL., respectively. The CUPRAC reducing power was determined as 4.69 and 9.57 TEACCUPRAC, respectively. Tyrosinase inhibitor activity were found to be 86.95 and 196.7 µg/mL. Both lichens did not show antimicrobial effects. As a result of the antioxidant and tyrosinase inhibitor activities it was seen that their activities were significant and further in vivo studies could be carried out on this lichens.