Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies


Lord P., Spiering R., Aguillon J. C. , Anderson A. E. , Appel S., Benitez-Ribas D., ...More

PEERJ, vol.4, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 4
  • Publication Date: 2016
  • Doi Number: 10.7717/peerj.2300
  • Title of Journal : PEERJ
  • Keywords: Cell therapy, Minimum information model, Antigen-presenting cells, Autoimmune disease, Transplantation, Tolerogenic dendritic cells, Regulatory macrophages, Reporting guidelines, DENDRITIC CELLS, DISEASE

Abstract

Cellular therapies, with tolerogenic antigen-presenting cells (tolAPC) show great promise for the treatment of autoimmune diseases and for the prevention of destructive immune responses after transplantation The methodologies for generating tolAPC vary greatly between different laboratories, making it difficult to compare data from different studies; thus constituting a major hurdle for the development of standardised tolAPC therapeutic products. Here we describe an initiative by members of the tolAPC field to generate a minimum information model for tolAPC (MITAP), providing a reporting framework that will make differences and similarities between tolAPC products transparent. In this way, MITAP constitutes a first but important step towards the production of standardised and reproducible tolAPC for clinical application.