Can new laboratory parameters be added for clinical scoring systems to determine the severity of RSV bronchiolitis?
Turkish Journal of Biochemistry, cilt.50, sa.5, ss.739-749, 2025 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 50 Sayı: 5
- Basım Tarihi: 2025
- Doi Numarası: 10.1515/tjb-2024-0190
- Dergi Adı: Turkish Journal of Biochemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Food Science & Technology Abstracts, Directory of Open Access Journals
- Sayfa Sayıları: ss.739-749
- Anahtar Kelimeler: N-terminal pro-B-type natriuretic peptide, PICU, pulmonary hypertension, respiratory syncytial virus, Tei index
- Bursa Uludağ Üniversitesi Adresli: Hayır
Özet
In this study, the aim is to investigate the clinical findings as well as laboratory and echocardiographic differences in infants with respiratory syncytial virus (RSV) bronchiolitis hospitalized in the pediatric intensive care unit (PICU) compared to those hospitalized in the general pediatric ward and thus contribute to the establishment of a novel evidence-based medical scoring. The study was conducted by retrospectively reviewing the files of 58 infants aged 1-12 months who were hospitalized in the PICU and general pediatric ward of Health Sciences University of Bursa City Hospital with a definite diagnosis of RSV bronchiolitis between September 2022 and April 2023. There were significant differences in clinical findings (Bronchiolitis Score of Sant Joan de Déu↑), laboratory tests [blood gas (pH↓-PaCO2↑-lactate↑) and N-terminal pro-B-type natriuretic peptide (NT-proBNP↑)] and echocardiographic parameters [systolic pulmonary artery pressure (sPAP↑), right ventricular Tei index (RVTX↑), left ventricular systolic eccentricity index (LVEls↑) and tricuspid annular planar systolic excursion (TAPSE↓)] in infants hospitalized in PICU compared to those hospitalized in general pediatric ward. Multivariate regression analysis revealed that the best indicator to add to the clinical score in terms of PICU hospitalization was NT-ProBNP (OR: 1.007, 95 % CI 1.002-1.011, p=0.003). The severity of RSV bronchiolitis can be evaluated more objectively with new scoring methods to be developed by adding laboratory and echocardiographic parameters, especially NT-proBNP, to clinical scoring systems.