Diurnal variation of steroid hormones and their reference intervals using mass spectrometric analysis

Parikh T. P. , Stolze B., Ozarda Y., Jonklaas J., Welsh K., Masika L., ...More

ENDOCRINE CONNECTIONS, vol.7, no.12, pp.1354-1361, 2018 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 12
  • Publication Date: 2018
  • Doi Number: 10.1530/ec-18-0417
  • Title of Journal : ENDOCRINE CONNECTIONS
  • Page Numbers: pp.1354-1361


Objective: Accurate measurement of steroid hormones remains challenging. Mass spectrometry affords a reliable means for quantitating steroid profiles accurately. Our objective was to establish and define (1) the extent of diurnal fluctuations in steroid concentrations that potentially necessitate strict adherence to time of sample acquisition and (2) time-dependent steroid reference intervals.