Methotrexate intoxication: Beyond the adverse events.

Dalkilic E. , Coskun B. N. , Yagiz B., Tufan A. N. , Ermurat S., PEHLİVAN Y.

International journal of rheumatic diseases, vol.21, no.8, pp.1557-1562, 2018 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 8
  • Publication Date: 2018
  • Doi Number: 10.1111/1756-185x.13339
  • Title of Journal : International journal of rheumatic diseases
  • Page Numbers: pp.1557-1562
  • Keywords: methotrexate, methotrexate toxicity, renal insufficiency, LOW-DOSE METHOTREXATE, RHEUMATOID-ARTHRITIS, ACID SUPPLEMENTATION, INDUCED PANCYTOPENIA, FOLINIC ACID, TOXICITY, THERAPY

Abstract

Aim: Methotrexate (MTX) is the first-line disease-modifying antirheumatic drug in rheumatoid arthritis (RA). However, this anchor may cause some side effects that may range from nausea to mortality. The clinical features of MTX toxicity are under-researched. In this study, we aimed to find out the potential predisposing factors and outcomes of the MTX toxicity (n = 31).