The REM-sleep-related characteristics of narcolepsy: a nation-wide multicenter study in Turkey, the REMCON study


AKYILDIZ U. O. , TEZER FİLİK F. İ. , Koc G., İSMAİLOĞULLARI S., Demir A. B. , Ak A. K. , ...More

SLEEP MEDICINE, vol.94, pp.17-25, 2022 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 94
  • Publication Date: 2022
  • Doi Number: 10.1016/j.sleep.2022.03.025
  • Journal Name: SLEEP MEDICINE
  • Journal Indexes: Science Citation Index Expanded, Scopus, Academic Search Premier, CINAHL, EMBASE, MEDLINE, Psycinfo
  • Page Numbers: pp.17-25
  • Keywords: Narcolepsy, REM sleep, REM sleep Without atonia, Rapid eye movement index, PERIODIC LEG MOVEMENTS, LATENCY TEST, EYE-MOVEMENTS, CATAPLEXY, MSLT, HYPERSOMNIA, TYPE-1, WAKEFULNESS, PREDICTORS, DIAGNOSIS

Abstract

Introduction: Narcolepsy type 1 (NT1) is caused by hypocretin deficiency, the pathophysiology of narcolepsy type 2 (NT2) has not been delineated. Except for the hypocretin deficiency and cataplexy, all clinical and laboratory features used in the diagnosis of NT2 are identical to those used for NT1. The aim of this study was to assess the rapid eye movement (REM) sleep-related characteristics in the patients with narcolepsy; the characteristics of REM sleep in polysomnography (PSG) and multiple sleep latency test (MSLT) recordings, the quantification of REM sleep without atonia (RSWA) and atonia index, and the analysis of rapid eye movements (REMs) during REM sleep.