The role of resistin in Beh double dagger et's disease: a Turkish experiment


Pehlivan Y., Onat A. M. , Okumus S., Kisacik B., Comez G., Comez A., ...More

MODERN RHEUMATOLOGY, vol.22, no.4, pp.571-575, 2012 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 4
  • Publication Date: 2012
  • Doi Number: 10.1007/s10165-011-0546-0
  • Journal Name: MODERN RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.571-575
  • Bursa Uludag University Affiliated: No

Abstract

The objective of this study was to assess the role of resistin, a proinflammatory cytokine potentially involved in Beh double dagger et's disease (BD), and to determine its relationship with tumor necrosis factor alpha (TNF-alpha), another important inflammatory cytokine known to be involved in BD. Forty-five persons diagnosed with BD were enrolled into this study, 25 of whom were being followed or had recently been diagnosed with clinically active BD, whereas the remaining 20 were previously diagnosed and had clinically inactive BD for the previous 3 months. Thirty persons were recruited as a healthy control group. Patients' C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), resistin, and TNF-alpha levels were determined with enzyme-linked immunosorbent assay (ELISA). Resistin and TNF-alpha levels were significantly higher in patients with BD (p < 0.05 and p < 0.05) than in the control group. The major interest of this study was to investigate the role of resistin in patients with BD. An elevated resistin level was associated with activation of BD. Elevated TNF-alpha and resistin levels could be determined simultaneously, and the presence of these two cytokines together suggests that resistin plays an important role in the pathogenesis and activation of BD.