Synthesis and Anticancer Activities of Water Soluble Schiff Base Metal Complexes Suda Çözünebilir Schiff Bazı Metal Komplekslerinin Sentezi ve Antikanser Aktivitesi
Adiyaman University Journal of Science, vol.10, no.2, pp.441-454, 2020 (Scopus, TRDizin)
- Publication Type: Article / Article
- Volume: 10 Issue: 2
- Publication Date: 2020
- Doi Number: 10.37094/adyujsci.738743
- Journal Name: Adiyaman University Journal of Science
- Journal Indexes: Scopus, TR DİZİN (ULAKBİM)
- Page Numbers: pp.441-454
- Keywords: Cell culture, Lung cancer, Metal complexes, Schiff base
- Bursa Uludag University Affiliated: No
Abstract
In this study, we synthesized the water-soluble Schiff Base containing S, O, N heteroatoms by the condensation reaction from 4-amino-3-hydroxynaphthalene-1-sulfonic acid and 2-hydroxy-3-methoxybenzaldehyde. In addition, Cu (II), Zn (II) and Ni (II) complexes of the ligand were synthesized and characterized by elemental analysis, magnetic susceptibility and spectroscopic techniques such as FT-IR,1H-NMR and13C-NMR. The anticancer activities of ligand and it’s three metal complexes on A549 lung cancer cell lines were evaluated. Cell viability experiments revealed that Ligand (L) and nickel (II) complex (L-Ni) did not able to inhibit A549 cell proliferation while L-Cu and L-Zn had 12 and 80 µM of IC50 values respectively. These last two complexes also induced apoptosis and suppressed cell migration on A549 cells.