Synthesis and Anticancer Activities of Water Soluble Schiff Base Metal Complexes Suda Çözünebilir Schiff Bazı Metal Komplekslerinin Sentezi ve Antikanser Aktivitesi

Saygideğer Demir B., Gönül İ., Gümüşgöz Çelik G., İpekbayrak S., SAYGIDEĞER Y.

Adiyaman University Journal of Science, cilt.10, sa.2, ss.441-454, 2020 (Scopus, TRDizin) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.37094/adyujsci.738743
  • Dergi Adı: Adiyaman University Journal of Science
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.441-454
  • Anahtar Kelimeler: Cell culture, Lung cancer, Metal complexes, Schiff base
  • Bursa Uludağ Üniversitesi Adresli: Hayır

Özet

In this study, we synthesized the water-soluble Schiff Base containing S, O, N heteroatoms by the condensation reaction from 4-amino-3-hydroxynaphthalene-1-sulfonic acid and 2-hydroxy-3-methoxybenzaldehyde. In addition, Cu (II), Zn (II) and Ni (II) complexes of the ligand were synthesized and characterized by elemental analysis, magnetic susceptibility and spectroscopic techniques such as FT-IR,1H-NMR and13C-NMR. The anticancer activities of ligand and it’s three metal complexes on A549 lung cancer cell lines were evaluated. Cell viability experiments revealed that Ligand (L) and nickel (II) complex (L-Ni) did not able to inhibit A549 cell proliferation while L-Cu and L-Zn had 12 and 80 µM of IC50 values respectively. These last two complexes also induced apoptosis and suppressed cell migration on A549 cells.