Central choline suppresses plasma renin response to graded haemorrhage in rats

Isbil-Buyukcoskun N., Ilcol Y. O., CANSEV M., Hamurtekin E., Ozluk K., Ulus I. H.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, vol.35, no.9, pp.1023-1031, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 35 Issue: 9
  • Publication Date: 2008
  • Doi Number: 10.1111/j.1440-1681.2008.04978.x
  • Journal Name: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1023-1031
  • Keywords: acetylcholine, blood pressure, catecholamine, choline, graded haemorrhage, intracerebroventricular, plasma renin activity, vasopressin, NICOTINIC ACETYLCHOLINE-RECEPTORS, ADRENAL TYROSINE-HYDROXYLASE, INJECTED CDP-CHOLINE, BLOOD-PRESSURE, CONSCIOUS RATS, INTRACEREBROVENTRICULAR CHOLINE, REVERSES HYPOTENSION, SYMPATHOADRENAL SYSTEM, HEART-RATE, INCREASES
  • Bursa Uludag University Affiliated: Yes

Abstract

1. Central administration of choline increases blood pressure in normotensive and hypotensive states by increasing plasma concentrations of vasopressin and catecholamines. We hypothesized that choline could also modulate the renin-angiotensin pathway, the third main pressor system in the body.