Central choline suppresses plasma renin response to graded haemorrhage in rats

Isbil-Buyukcoskun N., Ilcol Y. O., CANSEV M., Hamurtekin E., Ozluk K., Ulus I. H.

CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, cilt.35, sa.9, ss.1023-1031, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 9
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1111/j.1440-1681.2008.04978.x
  • Dergi Adı: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1023-1031
  • Anahtar Kelimeler: acetylcholine, blood pressure, catecholamine, choline, graded haemorrhage, intracerebroventricular, plasma renin activity, vasopressin, NICOTINIC ACETYLCHOLINE-RECEPTORS, ADRENAL TYROSINE-HYDROXYLASE, INJECTED CDP-CHOLINE, BLOOD-PRESSURE, CONSCIOUS RATS, INTRACEREBROVENTRICULAR CHOLINE, REVERSES HYPOTENSION, SYMPATHOADRENAL SYSTEM, HEART-RATE, INCREASES
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

1. Central administration of choline increases blood pressure in normotensive and hypotensive states by increasing plasma concentrations of vasopressin and catecholamines. We hypothesized that choline could also modulate the renin-angiotensin pathway, the third main pressor system in the body.