Association Between Thr21Met and Ser89Asn Polymorphisms of the Urotensin II Gene and Systemic Sclerosis

Pehlivan Y. , Gogebakan B., Oztuzcu S., Ozgen M., Cetin G. Y. , Bayraktar R., ...More

JOURNAL OF RHEUMATOLOGY, vol.39, no.1, pp.106-111, 2012 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 1
  • Publication Date: 2012
  • Doi Number: 10.3899/jrheum.110509
  • Title of Journal : JOURNAL OF RHEUMATOLOGY
  • Page Numbers: pp.106-111


Objective. Systemic sclerosis (SSc) is an autoimmune chronic fibrotic disorder. Urotensin II (U-IT) is predominantly a vasoactive peptide with fibrotic and prothrombotic features. Like endothelin-1 (ET-1), U-II could play an important role in SSc pathogenesis. We evaluated the possible role of the U-II gene polymorphisms (Thr21Met and Ser89Asn) in the genetic susceptibility to SSc in a Turkish population.