Association Between Thr21Met and Ser89Asn Polymorphisms of the Urotensin II Gene and Systemic Sclerosis

Pehlivan, YAVUZ; Gogebakan, Bulent; Oztuzcu, Serdar; Ozgen, Metin; Cetin, Gozde; Bayraktar, Recep; Cengiz, Beyhan; Kisacik, Bunyamin; Koca, Suleyman; Donmez, Salim; Sayarlioglu, Mehmet; Demiryurek, Abdullah; Onat, Ahmet

doi:10.3899/jrheum.110509

Association Between Thr21Met and Ser89Asn Polymorphisms of the Urotensin II Gene and Systemic Sclerosis

Pehlivan Y., Gogebakan B., Oztuzcu S., Ozgen M., Cetin G. Y., Bayraktar R., ...Daha Fazla

JOURNAL OF RHEUMATOLOGY, cilt.39, sa.1, ss.106-111, 2012 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 39 Sayı: 1
Basım Tarihi: 2012
Doi Numarası: 10.3899/jrheum.110509
Dergi Adı: JOURNAL OF RHEUMATOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.106-111
Bursa Uludağ Üniversitesi Adresli: Hayır

Özet

Objective. Systemic sclerosis (SSc) is an autoimmune chronic fibrotic disorder. Urotensin II (U-IT) is predominantly a vasoactive peptide with fibrotic and prothrombotic features. Like endothelin-1 (ET-1), U-II could play an important role in SSc pathogenesis. We evaluated the possible role of the U-II gene polymorphisms (Thr21Met and Ser89Asn) in the genetic susceptibility to SSc in a Turkish population.