Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome.

Yeganeh M., Henneke P., Rezaei N., Ehl S., Thiel D., Matamoros N., ...Daha Fazla

International archives of allergy and immunology, cilt.146, sa.3, ss.190-4, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 146 Sayı: 3
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1159/000115886
  • Dergi Adı: International archives of allergy and immunology
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.190-4
  • Anahtar Kelimeler: hyper IgE syndrome, toll-like receptor, TNF-alpha, TUMOR-NECROSIS-FACTOR, DEFICIENCY, SIGNALS, INNATE
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with 'cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent features such as progressive skeletal abnormalities. Defective signaling in the Toll-like receptor (TLR) pathways has been suggested as a responsible pathologic mechanism, however, in previous reports, 10 patients revealed no defect in inflammatory cytokine responses to different TLR ligands. Here, we report the increase in pro-inflammatory cytokines TNF-alpha and IL-8, following TLR2 and TLR4 stimulation in a larger cohort of 25 additional patients with HIES, and provide a meta-analysis of the TLR data in HIES. Copyright (C) 2008 S. Karger AG, Basel.