Functional Effects of Alagebrium (ALT-711)-Isolated Rat Carotid Artery

Toprak Ç., Sirmagul B., Yigitaslan S.

EURASIAN JOURNAL OF MEDICINE, vol.49, no.3, pp.188-192, 2017 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 3
  • Publication Date: 2017
  • Doi Number: 10.5152/eurasianjmed.2017.17046
  • Journal Name: EURASIAN JOURNAL OF MEDICINE
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.188-192
  • Keywords: Alagebrium, calcium channel blockage, carotid artery, nitric oxide, vasodilatation, GLYCATION END-PRODUCTS, CROSS-LINK BREAKER, RECEPTOR, ALT-711, AGES
  • Bursa Uludag University Affiliated: No

Abstract

Objective: In our study, the effects of glycosylated protein cross-link breaker, alagebrium was investigated on isolated rat carotid artery using myography. Alagebrium showed vasodilator effect on carotid artery rings; particularly, this effect was significantly increased in endothelium-intact rings.