Investigation of the Effect of Vitamin D On Multiple Sclerosis Patients Using Fingolimod D Vitamininin Fingolimod Tedavisi Alan Multipl Skleroz Hastaları Üzerine Etkisinin Araştırılması
Journal of Uludag University Medical Faculty, cilt.49, sa.3, ss.297-303, 2023 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 49 Sayı: 3
- Basım Tarihi: 2023
- Doi Numarası: 10.32708/uutfd.13366185
- Dergi Adı: Journal of Uludag University Medical Faculty
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.297-303
- Anahtar Kelimeler: Fingolimod, Multiple sclerosis, Vitamin D, Therapeutic treatment
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
Multiple Sclerosis (MS) is a chronic, inflammatory, and neurodegenerative disease of the central nervous system that begins in young adulthood. MS is the leading cause of non-traumatic disability in young adults. Vitamin D is known to have immunomodulatory properties, and its deficiency has been identified as an environmental risk factor for the development of MS and has been associated with disease activation. This study aimed to determine the effects of initial vitamin D levels and replacement on clinical and radiological outcome parameters of patients with MS diagnosed with fingolimod treatment. The medical records of 214 patients we followed up in our center for eight years were evaluated retrospectively. Vitamin level data were analyzed in 132 patients for pretreatment, 130 during treatment, and 98 for replacement therapy. Endpoints were radiological activation, annual attack rate, new attack, progression in EDSS, and no evidence of disease activity-3 (NEDA-3). No correlation was found between the initial vitamin D levels and clinical or radiological activation or progression of the disease in patients receiving fingolimod therapy. In patients with low vitamin levels, no difference was found in the outcome parameters of patients whose replacement therapy could not reach the desired values. No positive difference was observed when the subgroup with high disease activation was evaluated. In conclusion, no correlation was found between initial low serum vitamin D level or inadequate replacement and clinical and radiological worsening. However, there is a need for more comprehensive studies in which other risk factors and genetic polymorphisms specific to the Turkish population are evaluated.