The acute cardiorespiratory effects of centrally injected arachidonic acid; the mediation of prostaglandin E, D and F-2 alpha

Erkan L. G., Altinbas B., Guvenc G., Aydin B., Niaz N., YALÇIN M.

RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY, vol.242, pp.117-124, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 242
  • Publication Date: 2017
  • Doi Number: 10.1016/j.resp.2017.04.006
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.117-124
  • Keywords: Arachidonic acid, PGE, PGD PGF(2 alpha), Mean blood pressure, Heart rate, Tidal volume, Respiratory rate, Respiratory minute ventilation, Partial oxygen pressure, Partial carbon dioxide pressure, Intracerebroventricular, THROMBOXANE SIGNALING PATHWAY, HEMORRHAGED HYPOTENSIVE RATS, PHOSPHOLIPASE A(2) ACTIVATOR, CENTRAL HISTAMINERGIC SYSTEM, BREATHING MOVEMENTS, CARDIOVASCULAR REGULATION, PERIPHERAL MECHANISMS, RESPIRATORY SYSTEM, NORMOTENSIVE RATS, FETAL SHEEP
  • Bursa Uludag University Affiliated: Yes


Arachidonic acid (AA), which is released from synaptic membrane phospholipid by neuroreceptor-initiated activation of phospholipase A(2), is abundant in the brain and works as a neurotransmitter and/or neuromodulator in the central nervous system. Recently we reported that centrally injected AA generated pressor and hyperventilation effects by activating thromboxane A(2) (TXA(2)) signaling pathway. The present study was designed to investigate the mediation of other metabolites of AA such as prostaglandin (PG) D, PGE and PGF(2 alpha), alongside TXA(2) in the AA-evoked cardiorespiratory effects in anaesthetized rats.