Preparation and characterization of latanoprost-loaded PVA nanofibers as an ocular drug delivery system for glaucoma treatment


Altuntuğ Cesur M. İ., Osman B., Tümay Özer E., Kanmaz D., Baykara M., Karaca E.

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS, vol.73, no.9, pp.761-770, 2024 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 73 Issue: 9
  • Publication Date: 2024
  • Doi Number: 10.1080/00914037.2023.2213387
  • Journal Name: INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Chemical Abstracts Core, Chimica, Compendex, INSPEC
  • Page Numbers: pp.761-770
  • Keywords: Drug release, electrospinning, glaucoma, latanoprost, nanofiber, polyvinyl alcohol, CROSS-LINKING, RELEASE, HYDROGEL, MEMBRANES, GLUTARALDEHYDE
  • Bursa Uludag University Affiliated: Yes

Abstract

In this study, latanoprost-loaded polyvinyl alcohol (PVA/LAT) nanofibers were developed as an ocular drug delivery system for glaucoma treatment. The nanofibers were constructed via electrospinning and crosslinked by glutaraldehyde. The characterization studies were conducted by scanning electron microscopy, Fourier Transform infrared spectroscopy, Brunauer, Emmett, and Teller analyses, water contact angle measurements, and also swelling and degradation studies. The PVA/LAT nanofibers crosslinked with 0.5% glutaraldehyde solution for 20 min had a cumulative release of 52% for 23 days. The results demonstrated that the PVA/LAT nanofibers have a usage potential as an ocular drug delivery system for glaucoma treatment.