Serum glial cell line-derived neurotrophic factor levels and impulsivity in heroin addiction: a cross-sectional, case-control study of 129 heroin addicts


Kotan V. O. , Yuksel R. N. , Kotan Z., Okay I. T. , Topcuoglu C., ÖZKAYA G., ...More

PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, vol.28, no.2, pp.131-135, 2018 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 2
  • Publication Date: 2018
  • Doi Number: 10.1080/24750573.2017.1415186
  • Journal Name: PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.131-135
  • Keywords: Heroin addiction, glial cell line-derived neurotrophic factor, GDNF, impulsivity, anxiety, depression, NIGRAL DOPAMINERGIC-NEURONS, PARKINSONS-DISEASE, SUBSTANCE-USE, FACTOR GDNF, RAT MODEL, ASSOCIATION, DISORDERS, REWARD, SCHIZOPHRENIA, DEGENERATION

Abstract

OBJECTIVE: Glial cell line-derived neurotrophic factor (GDNF), being a protective of dopaminergic neurons, is reported to modulate addictive behaviours and have a role as a negative regulator for biochemical and behavioural adaptations to drug abuse. We aimed to reveal impulsivity and serum GDNF levels in patients with heroin addiction and investigate their relationships in order to contribute to the understanding of behavioural aspects and biological mechanisms in heroin addiction via this study.