PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, vol.28, no.2, pp.131-135, 2018 (Peer-Reviewed Journal)
Article / Article
PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
Science Citation Index Expanded, Scopus
Heroin addiction, glial cell line-derived neurotrophic factor, GDNF, impulsivity, anxiety, depression, NIGRAL DOPAMINERGIC-NEURONS, PARKINSONS-DISEASE, SUBSTANCE-USE, FACTOR GDNF, RAT MODEL, ASSOCIATION, DISORDERS, REWARD, SCHIZOPHRENIA, DEGENERATION
OBJECTIVE: Glial cell line-derived neurotrophic factor (GDNF), being a protective of dopaminergic neurons, is reported to modulate addictive behaviours and have a role as a negative regulator for biochemical and behavioural adaptations to drug abuse. We aimed to reveal impulsivity and serum GDNF levels in patients with heroin addiction and investigate their relationships in order to contribute to the understanding of behavioural aspects and biological mechanisms in heroin addiction via this study.