Serum glial cell line-derived neurotrophic factor levels and impulsivity in heroin addiction: a cross-sectional, case-control study of 129 heroin addicts

Kotan V. O., Yuksel R. N., Kotan Z., Okay I. T., Topcuoglu C., ÖZKAYA G., ...Daha Fazla

PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY, cilt.28, sa.2, ss.131-135, 2018 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 28 Sayı: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1080/24750573.2017.1415186
  • Dergi Adı: PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.131-135
  • Anahtar Kelimeler: Heroin addiction, glial cell line-derived neurotrophic factor, GDNF, impulsivity, anxiety, depression, NIGRAL DOPAMINERGIC-NEURONS, PARKINSONS-DISEASE, SUBSTANCE-USE, FACTOR GDNF, RAT MODEL, ASSOCIATION, DISORDERS, REWARD, SCHIZOPHRENIA, DEGENERATION
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

OBJECTIVE: Glial cell line-derived neurotrophic factor (GDNF), being a protective of dopaminergic neurons, is reported to modulate addictive behaviours and have a role as a negative regulator for biochemical and behavioural adaptations to drug abuse. We aimed to reveal impulsivity and serum GDNF levels in patients with heroin addiction and investigate their relationships in order to contribute to the understanding of behavioural aspects and biological mechanisms in heroin addiction via this study.