Intracerebroventricularly injected nesfatin-1 activates central cyclooxygenase and lipoxygenase pathways


Guvenc-Bayram G., Altinbas B., Iqbal A., Cerci E., UDUM D. , YILMAZ M. S. , ...More

AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, vol.226, 2020 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 226
  • Publication Date: 2020
  • Doi Number: 10.1016/j.autneu.2020.102670
  • Title of Journal : AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
  • Keywords: Nesfatin-1, Cyclooxygenase, Lipoxygenase, Hypothalamus, Intracerebroventricular, CRITICAL HEMORRHAGIC HYPOTENSION, PHOSPHOLIPASE A(2) ACTIVATOR, ENDOGENOUS CENTRAL HISTAMINE, BRAIN THROMBOXANE A(2), ARACHIDONIC-ACID, NITRIC-OXIDE, FOOD-INTAKE, INVOLVEMENT, SYSTEM, RATS

Abstract

Nesfatin-1 is a multifunctional neuropeptide having crucial autonomic roles. It is well known that nesfatin-1 collaborates with other central neuromodulatory systems, such as central corticotropin-releasing hormone, melanocortin, oxytocin, and cholinergic systems to show its autonomic effects. Central arachidonic acid cascade plays an important role to provide the homeostasis by exhibiting similar autonomic effects to nesfatin-1. Based on these similarities, the current study was designed to show the effects of intracerebroventricularly (ICV) injected nesfatin-1 on the hypothalamic arachidonic acid (AA) cascade.