Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats


TAŞ S. , ÇELİKLER KASIMOĞULLARI S. , Ziyanok-Ayvalik S. , SARANDÖL E. , Dirican M.

CELL BIOCHEMISTRY AND FUNCTION, vol.29, no.2, pp.108-113, 2011 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 29 Issue: 2
  • Publication Date: 2011
  • Doi Number: 10.1002/cbf.1729
  • Title of Journal : CELL BIOCHEMISTRY AND FUNCTION
  • Page Numbers: pp.108-113
  • Keywords: Ulva rigida, diabetes, oxidative stress, antioxidant status, hyperlipidemia, SERUM PARAOXONASE ACTIVITY, VANADYL SULFATE, MELLITUS, ANTIOXIDANT, EXTRACT, MICE, ATHEROSCLEROSIS, AMINOGUANIDINE, HYPERGLYCEMIA, COMPLICATIONS

Abstract

This study was designed to investigate the effects of Ulva rigida, one of the green algae, on the lipid profile and oxidative-antioxidative systems in streptozotocin-induced diabetic rats. Forty Wistar rats randomly divided into four groups: control (C), control + U. rigida extract (C + URE), diabetes (D) and diabetes + U. rigida extract (D + URE). U. rigida (2%) was administered in drinking water for 5 weeks after the induction of diabetes. U. rigida reduced the blood glucose, serum total cholesterol, triglyceride levels and plasma and tissue malondialdehyde (MDA) levels in the D + URE group. Insulin levels were significantly higher in the D + URE than those of the D group. Serum total cholesterol and tissue MDA levels were reduced in the C + URE group. Whole blood glutathione peroxidase and erythrocyte superoxide dismutase activities were higher in the D and C + URE groups compared with the C group. Paraoxonase and arylesterase activities were lower in the D group while U. rigida increased paraoxonase activities in C + URE and D + URE groups. This is the first study which showed U. rigida has antidiabetic and antihyperlipidemic effects and improves oxidative stress in diabetic rats. We conclude that U. rigida might have a potential use as a protective and/or therapeutic agent in diabetes mellitus. Copyright (C) 2011 John Wiley & Sons, Ltd.