Ulva rigida improves carbohydrate metabolism, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats

TAŞ S., ÇELİKLER KASIMOĞULLARI S., Ziyanok-Ayvalik S., SARANDÖL E., Dirican M.

CELL BIOCHEMISTRY AND FUNCTION, cilt.29, sa.2, ss.108-113, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 2
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1002/cbf.1729
  • Dergi Adı: CELL BIOCHEMISTRY AND FUNCTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.108-113
  • Anahtar Kelimeler: Ulva rigida, diabetes, oxidative stress, antioxidant status, hyperlipidemia, SERUM PARAOXONASE ACTIVITY, VANADYL SULFATE, MELLITUS, ANTIOXIDANT, EXTRACT, MICE, ATHEROSCLEROSIS, AMINOGUANIDINE, HYPERGLYCEMIA, COMPLICATIONS
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

This study was designed to investigate the effects of Ulva rigida, one of the green algae, on the lipid profile and oxidative-antioxidative systems in streptozotocin-induced diabetic rats. Forty Wistar rats randomly divided into four groups: control (C), control + U. rigida extract (C + URE), diabetes (D) and diabetes + U. rigida extract (D + URE). U. rigida (2%) was administered in drinking water for 5 weeks after the induction of diabetes. U. rigida reduced the blood glucose, serum total cholesterol, triglyceride levels and plasma and tissue malondialdehyde (MDA) levels in the D + URE group. Insulin levels were significantly higher in the D + URE than those of the D group. Serum total cholesterol and tissue MDA levels were reduced in the C + URE group. Whole blood glutathione peroxidase and erythrocyte superoxide dismutase activities were higher in the D and C + URE groups compared with the C group. Paraoxonase and arylesterase activities were lower in the D group while U. rigida increased paraoxonase activities in C + URE and D + URE groups. This is the first study which showed U. rigida has antidiabetic and antihyperlipidemic effects and improves oxidative stress in diabetic rats. We conclude that U. rigida might have a potential use as a protective and/or therapeutic agent in diabetes mellitus. Copyright (C) 2011 John Wiley & Sons, Ltd.