Rapid and accurate simultaneous determination of fosinopril sodium and hydrochlorothiazide in tablets by HPLC


Ozkan S., Akay C., Cevheroglu S., Senturk Z.

JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES, vol.24, no.7, pp.983-991, 2001 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 24 Issue: 7
  • Publication Date: 2001
  • Doi Number: 10.1081/jlc-100103424
  • Title of Journal : JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES
  • Page Numbers: pp.983-991

Abstract

A new, simple, precise, accurate, and rapid reverse-phase high performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous determination of fosinopril sodium and hydrochlorothiazide from-tablets. The procedure is based on the use of the RP-HPLC method with a UV detector. Each analysis requires no longer than 6 minutes. A reversed phase C-18 column with a mobile phase composed of a mixture of methanol: water (40.60, v/v), adjusted to pH 4 with 10% orthophosphoric acid, was used to separate both compounds with sulfamethoxazole, as an internal standard, in a reasonable time period.