Histological evaluation of wound healing performance of electrospun poly(vinyl alcohol)/sodium alginate as wound dressing in vivo

Coskun G., Karaca E., Ozyurtlu M., Özbek S., Yermezler A., Cavusoglu I.

BIO-MEDICAL MATERIALS AND ENGINEERING, vol.24, pp.1527-1536, 2014 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 24
  • Publication Date: 2014
  • Doi Number: 10.3233/bme-130956
  • Journal Name: BIO-MEDICAL MATERIALS AND ENGINEERING
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1527-1536
  • Keywords: Electrospinning, nanofiber, alginate, wound dressing, histological evaluation, in vivo, NORMAL HUMAN KERATINOCYTES, NANOFIBROUS MEMBRANE, SODIUM ALGINATE, FIBERS
  • Bursa Uludag University Affiliated: Yes

Abstract

Poly(vinyl alcohol)/sodium alginate nanofibrous mats were produced by electrospinning method at optimum process parameters. Evaluation of alginate-based electrospun nanofibrous mats as a wound dressing material and their comparison to commercially available wound dressings produced with conventional methods were carried out in vivo. Tissue specimens were examined histopathologically on 4th, 6th, 15th, 21st postoperative days. In contrast to other dressings it was observed that nanofibrous mat could survive on the wound crust in early stages of healing. In terms of epithelization, epidermis characteristics, vascularization and formation of hair follicles, nanofibrous mat showed the best healing performance. This could be explained with presence of nanofibrous mat acting as an artificial skin on the wound region until new tissue regenerated.