BCG vaccination in patients with severe combined immunodeficiency: complications, risks, and vaccination policies.

Marciano B. E. , Huang C., Joshi G., Rezaei N., Carvalho B. C. , Allwood Z., ...More

The Journal of allergy and clinical immunology, vol.133, no.4, pp.1134-41, 2014 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 133 Issue: 4
  • Publication Date: 2014
  • Doi Number: 10.1016/j.jaci.2014.02.028
  • Title of Journal : The Journal of allergy and clinical immunology
  • Page Numbers: pp.1134-41
  • Keywords: Primary immunodeficiency, severe combined immunodeficiency, vaccine, BCG, mycobacteria, newborn screening, hematopoietic stem cell transplant, immune reconstitution syndrome, BACILLUS-CALMETTE-GUERIN, CENTRAL-NERVOUS-SYSTEM, IMMUNOCOMPROMISED CHILDREN, TUBERCULOUS MENINGITIS, VACCINES

Abstract

Background: Severe combined immunodeficiency (SCID) is a syndrome characterized by profound T-cell deficiency. BCG vaccine is contraindicated in patients with SCID. Because most countries encourage BCG vaccination at birth, a high percentage of patients with SCID are vaccinated before their immune defect is detected.