Conventional Amphotericin B Associated Nephrotoxicity in Patients With Hematologic

Gursoy V., ÖZKALEMKAŞ F., ÖZKOCAMAN V., Yegen Z. S., PINAR İ. E., ENER B., ...More

CUREUS, vol.13, no.7, 2021 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 13 Issue: 7
  • Publication Date: 2021
  • Doi Number: 10.7759/cureus.16445
  • Journal Name: CUREUS
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Keywords: conventional amphotericin b, nephrotoxicity, hematological malignancy, hypokalemia, fungal infections, ACUTE-RENAL-FAILURE, RISK-FACTORS, PREVENTION, THERAPY
  • Bursa Uludag University Affiliated: Yes

Abstract

Introduction: Amphotericin B (AmB-d) is one of the most effective therapeutic options against frequently life-threatening systemic fungal infections in patients with hematologic malignancies. However, significant adverse effects including nephrotoxicity associated with its use limit its more widespread use. The objectives of our study were to determine the incidence of AmB-d associated nephrotoxicity, to evaluate clinical and epidemiological characteristics of patients, and to support the notion that conventional amphotericin B remains a valid therapeutic option among hematologic patients with proper patient selection.