Successful treatment of acquired haemophilia with prednisolone therapy

Ali R., Ozcelik T., Ozkalemkas F., Ozkocaman V., Ozan U., Yalcin M., ...More

HAEMOPHILIA, vol.9, no.6, pp.741-743, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 6
  • Publication Date: 2003
  • Doi Number: 10.1046/j.1351-8216.2003.00830.x
  • Journal Name: HAEMOPHILIA
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.741-743
  • Bursa Uludag University Affiliated: Yes


Acquired hemophilia is a rare, life threatening coagulopathy in adults caused by the development of autoantibodies against to factor VIII. No general consensus exists on the best therapeutic approach. We report here a case that presented with extensive cutaneous and mucosal bleedings due to factor VIII inhibitors and treated successfully with steroid therapy alone but complicated with a life threatening thromboembolic attack during her follow up. In conclusion, corticosteroids are "cost effective therapy" associated with high inhibitor elimination rates and although recurrence of inhibitor in a patient with factor VIII inhibitor is an expected clinical situation thrombosis risk should also be considered.