Successful treatment of acquired haemophilia with prednisolone therapy
HAEMOPHILIA, cilt.9, sa.6, ss.741-743, 2003 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9 Sayı: 6
- Basım Tarihi: 2003
- Doi Numarası: 10.1046/j.1351-8216.2003.00830.x
- Dergi Adı: HAEMOPHILIA
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.741-743
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
Acquired hemophilia is a rare, life threatening coagulopathy in adults caused by the development of autoantibodies against to factor VIII. No general consensus exists on the best therapeutic approach. We report here a case that presented with extensive cutaneous and mucosal bleedings due to factor VIII inhibitors and treated successfully with steroid therapy alone but complicated with a life threatening thromboembolic attack during her follow up. In conclusion, corticosteroids are "cost effective therapy" associated with high inhibitor elimination rates and although recurrence of inhibitor in a patient with factor VIII inhibitor is an expected clinical situation thrombosis risk should also be considered.