Changes in salivary analytes in canine parvovirus: A high-resolution quantitative proteomic study

Franco-Martinez L., Tvarijonaviciute A., Horvatic A., Guillemin N., Joaquin Ceron J., Escribano D., ...Daha Fazla

COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES, cilt.60, ss.1-10, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 60
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1016/j.cimid.2018.09.011
  • Dergi Adı: COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1-10
  • Anahtar Kelimeler: Bioinformatics, Biomarker, Canine parvovirosis, Dog, Label-based proteomics, Saliva, HISTIDINE-RICH GLYCOPROTEIN, ACUTE-PHASE PROTEINS, DOGS, BIOMARKERS, INFECTION, IDENTIFICATION, DIAGNOSIS, ENTERITIS, LIPOCALIN, SERUM
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

The present study evaluated the changes in salivary proteome in parvoviral enteritis (PVE) in dogs through a high-throughput quantitative proteomic analysis. Saliva samples from healthy dogs and dogs with severe parvovirosis that survived or perished due to the disease were analysed and compared by Tandem Mass Tags (TMT) analysis. Proteomic analysis quantified 1516 peptides, and 287 (corresponding to 190 proteins) showed significantly different abundances between studied groups. Ten proteins were observed to change significantly between dogs that survived or perished due to PVE.