Assessment of CD39 expression in regulatory T-cell subsets by disease severity in adult and juvenile COVID-19 cases

Simsek A., Kizmaz M. A., Cagan E., Dombaz F., Tezcan G., Asan A., ...Daha Fazla

JOURNAL OF MEDICAL VIROLOGY, cilt.94, sa.5, ss.2089-2101, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 94 Sayı: 5
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1002/jmv.27593
  • Dergi Adı: JOURNAL OF MEDICAL VIROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.2089-2101
  • Anahtar Kelimeler: CD39, COVID-19, FoxP3, infectious diseases, Tregs
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

COVID-19 is a disease characterized by acute respiratory failure and is a major health problem worldwide. Here, we aimed to investigate the role of CD39 expression in Treg cell subsets in COVID-19 immunopathogenesis and its relationship to disease severity. One hundred and ninety COVID-19 patients (juveniles, adults) and 43 volunteers as healthy controls were enrolled in our study. Flow cytometric analysis was performed using a 10-color monoclonal antibody panel from peripheral blood samples. In adult patients, CD39(+) Tregs increased with disease severity. In contrast, CD39(+) Tregs were decreased in juvenile patients in an age-dependent manner. Overall, our study reveals an interesting profile of CD39-expressing Tregs in adult and juvenile cases of COVID-19. Our results provide a better understanding of the possible role of Tregs in the mechanism of immune response in COVID-19 cases.