Assessment of CD39 expression in regulatory T-cell subsets by disease severity in adult and juvenile COVID-19 cases
JOURNAL OF MEDICAL VIROLOGY, cilt.94, sa.5, ss.2089-2101, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 94 Sayı: 5
- Basım Tarihi: 2022
- Doi Numarası: 10.1002/jmv.27593
- Dergi Adı: JOURNAL OF MEDICAL VIROLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
- Sayfa Sayıları: ss.2089-2101
- Anahtar Kelimeler: CD39, COVID-19, FoxP3, infectious diseases, Tregs
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
COVID-19 is a disease characterized by acute respiratory failure and is a major health problem worldwide. Here, we aimed to investigate the role of CD39 expression in Treg cell subsets in COVID-19 immunopathogenesis and its relationship to disease severity. One hundred and ninety COVID-19 patients (juveniles, adults) and 43 volunteers as healthy controls were enrolled in our study. Flow cytometric analysis was performed using a 10-color monoclonal antibody panel from peripheral blood samples. In adult patients, CD39(+) Tregs increased with disease severity. In contrast, CD39(+) Tregs were decreased in juvenile patients in an age-dependent manner. Overall, our study reveals an interesting profile of CD39-expressing Tregs in adult and juvenile cases of COVID-19. Our results provide a better understanding of the possible role of Tregs in the mechanism of immune response in COVID-19 cases.