Kainic acid activates oxytocinergic neurons through non-NMDA glutamate receptors

Minbay F. Z., Eyigor Ö., Cavusoglu I.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, cilt.116, sa.5, ss.587-600, 2006 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 116 Sayı: 5
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1080/00207450600592123
  • Dergi Adı: INTERNATIONAL JOURNAL OF NEUROSCIENCE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.587-600
  • Anahtar Kelimeler: CNQX, immunohistochemistry, kainate, oxytocin, PVN, SON, METHYL-D-ASPARTATE, HYPOTHALAMIC PARAVENTRICULAR NUCLEUS, SUBUNIT MESSENGER-RNAS, RAT HYPOTHALAMUS, SUPRAOPTIC NUCLEUS, MAGNOCELLULAR NEURONS, SYNAPTIC CURRENTS, LACTATING RAT, IN-VITRO, EXPRESSION
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

The present study assessed if kainic acid activates oxytocinergic neurons and this activation is blocked by 6- cyano- 7- nitroquinoxaline- 2,3- dione ( CNQX). Dual immunohistochemistry for oxytocin and c- Fos showed that oxytocin neurons in SON and PVN express c- Fos following kainic acid administration, a significant increase when compared to the control group. Administration of CNQX prior to kainic acid caused a significant reduction. The results suggested the participation of non- NMDA receptors in the regulation of oxytocin neurons because the administration of kainic acid activates these neurons and this activation is blocked by CNQX administration.