Kainic acid activates oxytocinergic neurons through non-NMDA glutamate receptors

Minbay F. Z., Eyigor Ö., Cavusoglu I.

INTERNATIONAL JOURNAL OF NEUROSCIENCE, vol.116, no.5, pp.587-600, 2006 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 116 Issue: 5
  • Publication Date: 2006
  • Doi Number: 10.1080/00207450600592123
  • Journal Name: INTERNATIONAL JOURNAL OF NEUROSCIENCE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.587-600
  • Keywords: CNQX, immunohistochemistry, kainate, oxytocin, PVN, SON, METHYL-D-ASPARTATE, HYPOTHALAMIC PARAVENTRICULAR NUCLEUS, SUBUNIT MESSENGER-RNAS, RAT HYPOTHALAMUS, SUPRAOPTIC NUCLEUS, MAGNOCELLULAR NEURONS, SYNAPTIC CURRENTS, LACTATING RAT, IN-VITRO, EXPRESSION
  • Bursa Uludag University Affiliated: Yes

Abstract

The present study assessed if kainic acid activates oxytocinergic neurons and this activation is blocked by 6- cyano- 7- nitroquinoxaline- 2,3- dione ( CNQX). Dual immunohistochemistry for oxytocin and c- Fos showed that oxytocin neurons in SON and PVN express c- Fos following kainic acid administration, a significant increase when compared to the control group. Administration of CNQX prior to kainic acid caused a significant reduction. The results suggested the participation of non- NMDA receptors in the regulation of oxytocin neurons because the administration of kainic acid activates these neurons and this activation is blocked by CNQX administration.