Genetic contribution of SCARB1 variants to lipid traits in African Blacks: a candidate gene association study


Niemsiri V., Wang X., PİRİM D., Radwan Z. H. , Bunker C. H. , Barmada M. M. , ...More

BMC MEDICAL GENETICS, vol.16, 2015 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16
  • Publication Date: 2015
  • Doi Number: 10.1186/s12881-015-0250-6
  • Journal Name: BMC MEDICAL GENETICS
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Keywords: African continental ancestry group, Candidate gene association study, Genetic variation, Haplotypes, Lipids, SCARB1 protein, human, Sequence analysis, DNA, HIGH-DENSITY-LIPOPROTEIN, SCAVENGER RECEPTOR BI, HDL CHOLESTEROL LEVELS, SR-BI, I GENE, TARGETED MUTATION, COMMON VARIANTS, PLASMA-LEVELS, METABOLISM, POLYMORPHISMS

Abstract

Background: High-density lipoprotein cholesterol (HDL-C) exerts many anti-atherogenic properties including its role in reverse cholesterol transport (RCT). Scavenger receptor class B member 1 (SCARB1) plays a key role in RCT by selective uptake of HDL cholesteryl esters. We aimed to explore the genetic contribution of SCARB1 to affecting lipid levels in African Blacks from Nigeria.