Genetic contribution of SCARB1 variants to lipid traits in African Blacks: a candidate gene association study

Niemsiri, Vipavee; Wang, Xingbin; PİRİM, DİLEK; Radwan, Zaheda; Bunker, Clareann; Barmada, M.; Kamboh, M.; Demirci, F.

doi:10.1186/s12881-015-0250-6

Genetic contribution of SCARB1 variants to lipid traits in African Blacks: a candidate gene association study

Niemsiri V., Wang X., PİRİM D., Radwan Z. H., Bunker C. H., Barmada M. M., ...Daha Fazla

BMC MEDICAL GENETICS, cilt.16, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 16
Basım Tarihi: 2015
Doi Numarası: 10.1186/s12881-015-0250-6
Dergi Adı: BMC MEDICAL GENETICS
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Anahtar Kelimeler: African continental ancestry group, Candidate gene association study, Genetic variation, Haplotypes, Lipids, SCARB1 protein, human, Sequence analysis, DNA, HIGH-DENSITY-LIPOPROTEIN, SCAVENGER RECEPTOR BI, HDL CHOLESTEROL LEVELS, SR-BI, I GENE, TARGETED MUTATION, COMMON VARIANTS, PLASMA-LEVELS, METABOLISM, POLYMORPHISMS
Bursa Uludağ Üniversitesi Adresli: Hayır

Özet

Background: High-density lipoprotein cholesterol (HDL-C) exerts many anti-atherogenic properties including its role in reverse cholesterol transport (RCT). Scavenger receptor class B member 1 (SCARB1) plays a key role in RCT by selective uptake of HDL cholesteryl esters. We aimed to explore the genetic contribution of SCARB1 to affecting lipid levels in African Blacks from Nigeria.