BMC MEDICAL GENETICS, vol.16, 2015 (Peer-Reviewed Journal)
Article / Article
BMC MEDICAL GENETICS
Science Citation Index Expanded, Scopus
African continental ancestry group, Candidate gene association study, Genetic variation, Haplotypes, Lipids, SCARB1 protein, human, Sequence analysis, DNA, HIGH-DENSITY-LIPOPROTEIN, SCAVENGER RECEPTOR BI, HDL CHOLESTEROL LEVELS, SR-BI, I GENE, TARGETED MUTATION, COMMON VARIANTS, PLASMA-LEVELS, METABOLISM, POLYMORPHISMS
Background: High-density lipoprotein cholesterol (HDL-C) exerts many anti-atherogenic properties including its role in reverse cholesterol transport (RCT). Scavenger receptor class B member 1 (SCARB1) plays a key role in RCT by selective uptake of HDL cholesteryl esters. We aimed to explore the genetic contribution of SCARB1 to affecting lipid levels in African Blacks from Nigeria.