Effect of Saccharomyces boulardii in children with acute gastroenteritis and its relationship to the immune response
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH, cilt.35, sa.2, ss.201-212, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 2
- Basım Tarihi: 2007
- Doi Numarası: 10.1177/147323000703500204
- Dergi Adı: JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.201-212
- Anahtar Kelimeler: probioitics, Saccharomyces boulardii, gastroenteritis, children, breast-feeding, immune response, paediatrics, ANTIBIOTIC-ASSOCIATED DIARRHEA, PLACEBO-CONTROLLED TRIAL, LACTOBACILLUS GG, T-CELLS, PREVENTION, PROBIOTICS, DISEASE, INFANTS, BETA
- Bursa Uludağ Üniversitesi Adresli: Evet
Özet
We evaluated the effect of Saccharomyces boulardii administration in otherwise healthy children aged between 6 months and 10 years who were admitted for acute diarrhoea (15 males, 12 females). The patients were randomized into two groups: group 1 (n = 16) received 250 mg S. boulardii dissolved in 5 ml of water orally twice daily for 7 days and group 2 (n = 11) received placebo. Clinical and laboratory assessments were performed on admission and on day 7 of follow-up. Both groups experienced reduced daily stool frequency, the decrease being significantly greater in group 1 on days 3 and 4 compared with group 2. Group I demonstrated significant increases in serum immunoglobulin A and decreases in C-reactive protein levels on day 7. The percentage of CD8 lymphocytes on day 7 was significantly higher in group I than group 2. This study confirmed the efficacy of S. boulardii in paediatric acute gastroenteritis and the findings suggest that S. boulardii treatment enhances the immune response.