Common fragile site expression and genetic predisposition to breast cancer.

Cecener G., Egeli Ü., Tasdelen I., Tunca B., Duman H., Kizil A.

Teratogenesis, carcinogenesis, and mutagenesis, cilt.18, sa.6, ss.279-91, 1998 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 6
  • Basım Tarihi: 1998
  • Dergi Adı: Teratogenesis, carcinogenesis, and mutagenesis
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.279-91
  • Anahtar Kelimeler: breast cancer, fragile sites, genetic susceptibility, chromosomal abnormalities, aphidicolin, caffeine, LUNG CANCERS, CHROMOSOME BREAKPOINTS, APHIDICOLIN, LYMPHOCYTES
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

The expression of common fragile sites induced by aphidicolin and caffeine was evaluated on prometaphase obtained from the peripheral blood lymphocytes of 35 women with breast cancer, their 35 clinically healthy female family members, and 20 sex- and age-matched normal controls. As a result of the cytogenetic and statistical evaluation, the number of damaged cells, chromosomal aberrations, and expression frequencies of fragile sites detected in patients with breast cancer and their first-degree relatives were found to be significantly higher than those in the control group. Our findings indicate an increased genetic instability in women with breast carcinomas and their relatives. Therefore, fragile sites may be used as a reliable marker for defining genetic susceptibility to cancer in general.