Low-dose clonidine and neostigmine prolong the duration of intrathecal bupivacaine-fentanyl for labor analgesia

Owen M., Ozsarac O., Sahin S., Uckunkaya N., Kaplan N., Magunaci I.

ANESTHESIOLOGY, vol.92, no.2, pp.361-366, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 92 Issue: 2
  • Publication Date: 2000
  • Doi Number: 10.1097/00000542-200002000-00016
  • Journal Name: ANESTHESIOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.361-366
  • Bursa Uludag University Affiliated: No


Background: Intrathecal (IT) opioid and local anesthetic combinations are popular for labor analgesia because of rapid, effective pain relief, but the duration of analgesia is limited. This study was undertaken to determine whether the addition of clonidine and neostigmine to IT bupivacaine-fentanyl would increase the duration of analgesia without increasing side effects for patients in labor.