Long-term outcome of the fetal adrenal gland transplantation in rats


Kiristioglu İ., Dogruyol H., Cavusoglu I.

EUROPEAN JOURNAL OF PEDIATRIC SURGERY, vol.9, no.6, pp.400-405, 1999 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 6
  • Publication Date: 1999
  • Doi Number: 10.1055/s-2008-1072292
  • Journal Name: EUROPEAN JOURNAL OF PEDIATRIC SURGERY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.400-405

Abstract

Three experimental groups have been constructed to evaluate the long-term outcome of fetal adrenal transplantation in rats. In Group 1 (n = 10), rats underwent bilateral adrenalectomy. In Group 2 (n = 10), rats underwent a sham procedure which included flank incision and arterial canulization. In Group 3 (n = 20), a left adrenalectomy was performed followed immediately by transplantation of a fetal adrenal graft into the greater omentum and marked with a prolene suture (Stage 1). One year later, the right adrenal gland of the recipient was removed followed by a determination of the fetal adrenal graft function (Stage 2). Craft function was evaluated by measuring ACTH and corticosterone levels; and a histologic examination of the transplanted fetal adrenal gland was obtained at autopsy.