Effects of periodontal therapy on disease activity and systemic inflammation in rheumatoid arthritis patients


Erciyas K., Sezer U., Ustun K., Pehlivan Y., Kisacik B., Senyurt S. Z. , ...More

ORAL DISEASES, vol.19, no.4, pp.394-400, 2013 (Peer-Reviewed Journal) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 4
  • Publication Date: 2013
  • Doi Number: 10.1111/odi.12017
  • Journal Name: ORAL DISEASES
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.394-400
  • Keywords: cytokine, disease activity, periodontal treatment, periodontitis, rheumatoid arthritis, C-REACTIVE PROTEIN, NECROSIS-FACTOR-ALPHA, SERUM, SEVERITY, CYTOKINE, MARKERS, ASSOCIATION, INFECTION, CRITERIA, LEVEL

Abstract

Objective This observational prospective cohort study aimed to evaluate the effects of non-surgical periodontal treatment on clinical periodontal measurements and systemic inflammatory mediator levels in low or moderate to highly active rheumatoid arthritis (RA) patients with chronic periodontitis. Subjects and methods Rheumatoid arthritis activity was assessed with disease activity score test (DAS28). Thirty patients with RA with moderate to high disease activity (DAS283.2) and chronic periodontitis (MHDA group) and thirty patients with RA with low disease activity (DAS28<3.2) and chronic periodontitis (LDA group) were enrolled in the study. The patients were monitored at the beginning and 3months after undergoing periodontal therapy. Erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), tumour necrosis factor-alpha (TNF-) levels in serum, DAS28 and periodontal parameters were evaluated. Results Erythrocyte sedimentation rate, CRP, TNF- levels in serum, DAS28 and periodontal parameters exhibited similar and significant reduction 3months after the non-surgical periodontal treatment. Conclusion Non-surgical periodontal treatment may prove beneficial in reducing RA severity as measured by ESR, CRP, TNF- levels in serum and DAS28 in low or moderate to highly active RA patients with chronic periodontitis. Oral Diseases (2013) 19, 394-400