The role of preoperative serum levels for Dickkopf-related protein 1 as a potential marker of tumor invasion in patients with stage II and III colon cancer
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.18, sa.12, ss.1742-1747, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 18 Sayı: 12
- Basım Tarihi: 2014
- Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.1742-1747
- Anahtar Kelimeler: CEA, DKK-1, Stage II, Stage III, Colon cancer, CEA
- Bursa Uludağ Üniversitesi Adresli: Hayır
Özet
OBJECTIVES: To determine and correlate preoperative serum levels of CEA and Dickkopf-related protein 1 (DKK-1) in stage II and III colon cancer and so identify the patients at high risk for early relapse. PATIENTS AND METHODS: A total of 100 patients with stage II (n = 50; median age: 53 years, 31 males) and III (n = 50; median age: 57 years, 32 males) colon cancer and 50 controls (median age: 53.9 years, 25 males) were included. Serum levels for CEA and DKK-1 were recorded in each subject. RESULTS: Mean (SD) levels for serum CEA and DKK-1 were significantly higher in stage III patients than in stage II patients and controls (p < 0.001 for each). There was a significant correlation between serum levels of CEA and DKK-1 in stage II (r = 0.71, p < 0.001) stage III (r = 0.62, p < 0.001) patients. CONCLUSIONS: Preoperative serum levels for DKK-1 seem to be a potential marker in prediction of tumor invasion and relapse in stage II-III colon cancer.