Lipopolysaccharide-induced hypotension is mediated by a neural pathway involving the vagus nerve, the nucleus tractus solitarius and alpha-adrenergic receptors in the preoptic anterior hypothalamic area


Yilmaz M. S. , Goktalay G., Millington W. R. , Myer B. S. , Cutrera R. A. , Feleder C.

JOURNAL OF NEUROIMMUNOLOGY, vol.203, no.1, pp.39-49, 2008 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 203 Issue: 1
  • Publication Date: 2008
  • Doi Number: 10.1016/j.jneuroim.2008.06.023
  • Journal Name: JOURNAL OF NEUROIMMUNOLOGY
  • Journal Indexes: Science Citation Index Expanded, Scopus
  • Page Numbers: pp.39-49
  • Keywords: Endotoxic shock, Hypotension, Vagus nerve, Nucleus tractus solitarius, Alpha-adrenergic receptors, TUMOR-NECROSIS-FACTOR, C-FOS EXPRESSION, SUBDIAPHRAGMATIC VAGOTOMY, NITRIC-OXIDE, TNF-ALPHA, BODY-TEMPERATURE, ENDOTOXIC FEVER, GUINEA-PIGS, CYTOKINES, RAT

Abstract

We recently reported that the preoptic anterior hypothalamic area (POA) mediates the hypotensive response evoked by lipopolysaccharide (LPS). In this study, we investigated how the inflammatory signal induced by Lips reaches the POA. Subdiaphragmatic vagotomy and abdominal perivagal lidocaine administration, or lidocaine injection into the nucleus tractus solitarius (NTS) prevented LPS hypotension. Microinjection of the alpha-adrenergic receptor antagonist phentolamine into the POA, blocked initiation of the hypotensive response and prevented the late decompensatory phase. These data suggest that LPS hypotension is mediated by the vagus nerve which conveys the signal to the NTS and, in turn, stimulates norepinephrine release within the POA. (C) 2008 Elsevier B.V. All rights reserved.