The study of Islamic Arabic manuscripts in West Africa is a matter of neglect by researchers, except in a few cases in Mali, Nigeria, Niger, Ghana and Senegal. Despite the enormous intellectual works that the Guinean scholars have presented in so many aspects of the Islamic culture in the Arabic language, we can hardly find serious studies concerned with this valuable heritage with regards to collection and analysis. West African scholars have left a very rich intellectual and cultural heritage in the Arabic language in terms of the number and diversity of topics and arts that they discussed. Unfortunately, these scholarly works(manuscripts) have not received the attention they deserve in terms of preservation, digitalization and publishing. Despite their scientific importance, cultural distinction, Islamic characteristics and they serving as essential sources in the cultural and historical studies of West Africa. The research consisted of an introduction and a conclusion, mediated by five main chapters, which analyzed the scholarly works of West African scholars and described the reality and state of those works (manuscripts) in Guinea as a case study. The chapters also presented solutions and suggestions on ways to preserve and publish manuscripts in Guinea.