THE BENEFICIAL EFFECT OF CYCLOSPORINE-A ON THE NO-REFLOW PHENOMENON IN RAT SKIN ISLAND FLAPS

KUCUKCELEBI A., OZCAN M.

BRITISH JOURNAL OF PLASTIC SURGERY, cilt.45, sa.7, ss.512-514, 1992 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 45 Sayı: 7
  • Basım Tarihi: 1992
  • Doi Numarası: 10.1016/0007-1226(92)90144-m
  • Dergi Adı: BRITISH JOURNAL OF PLASTIC SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, Gender Studies Database, MEDLINE, MLA - Modern Language Association Database
  • Sayfa Sayıları: ss.512-514
  • Bursa Uludağ Üniversitesi Adresli: Hayır

Özet

The no-reflow phenomenon is one of the factors that increase morbidity in flap and replantation surgery. Prevention and treatment of the phenomenon is an area of intense current research. This study investigated the possible effect of cyclosporin administered systemically on survival of skin flaps subjected to ischaemia-reperfusion injury. Cyclosporin treated flaps showed a statistically significant increase in survival areas regardless of the time of infusion (p < 0.01). These findings suggest that cyclosporin could be valuable in preventing or treating no-reflow in critical flaps. Possible mechanisms of action are discussed.