THE BENEFICIAL EFFECT OF CYCLOSPORINE-A ON THE NO-REFLOW PHENOMENON IN RAT SKIN ISLAND FLAPS


KUCUKCELEBI A., OZCAN M.

BRITISH JOURNAL OF PLASTIC SURGERY, vol.45, no.7, pp.512-514, 1992 (Peer-Reviewed Journal) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 7
  • Publication Date: 1992
  • Doi Number: 10.1016/0007-1226(92)90144-m
  • Journal Name: BRITISH JOURNAL OF PLASTIC SURGERY
  • Journal Indexes: Science Citation Index Expanded, Scopus, EMBASE, Gender Studies Database, MEDLINE, MLA - Modern Language Association Database
  • Page Numbers: pp.512-514

Abstract

The no-reflow phenomenon is one of the factors that increase morbidity in flap and replantation surgery. Prevention and treatment of the phenomenon is an area of intense current research. This study investigated the possible effect of cyclosporin administered systemically on survival of skin flaps subjected to ischaemia-reperfusion injury. Cyclosporin treated flaps showed a statistically significant increase in survival areas regardless of the time of infusion (p < 0.01). These findings suggest that cyclosporin could be valuable in preventing or treating no-reflow in critical flaps. Possible mechanisms of action are discussed.