Importance of p53, bcl-2, p21(WAF1) and PCNA positivities in renal angiomyolipomas

BUDAK M., Yalcin O., USTA U., TOKUÇ B.

BIOMEDICAL RESEARCH-INDIA, vol.28, no.10, pp.4696-4702, 2017 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 28 Issue: 10
  • Publication Date: 2017
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Academic Search Premier, Chemical Abstracts Core
  • Page Numbers: pp.4696-4702
  • Bursa Uludag University Affiliated: Yes


Angiomyolipomas are tumors of the kidneys which are often benign in character with a potential for malignant transformation. The benign-malign distinction in these tumors can be made only with clinical follow-up as they exhibit the same microscopic appearance. In the present study, immunohistochemical investigation has been performed for p53, p21(WAF1), PCNA and bcl-2, which may be markers for the histological distinction of benign and malignant cases. The p53, p21WAF1, PCNA and bcl-2 investigations in 10 tumor tissues with AML revealed significantly higher p53 positivity in 3 patients. The clinical follow-up of these three patients showed malignant progression. In conclusion, we believe that p53 positivity may be an appropriate marker for the benign-malign distinction in AML tumors.