Serum monocyte chemoattractant protein-1 and monocyte adhesion molecules in type 1 diabetic patients with nephropathy


Kiyici S., Erturk E., Budak F. , Ersoy C., Tuncel E., Duran C., ...More

ARCHIVES OF MEDICAL RESEARCH, vol.37, no.8, pp.998-1003, 2006 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 37 Issue: 8
  • Publication Date: 2006
  • Doi Number: 10.1016/j.arcmed.2006.06.002
  • Title of Journal : ARCHIVES OF MEDICAL RESEARCH
  • Page Numbers: pp.998-1003
  • Keywords: diabetic nephropathy, MCP-1, adhesion molecules, ENDOTHELIAL DYSFUNCTION, EXPRESSION, RECRUITMENT, MACROPHAGES, ACTIVATION, CHEMOKINES, CYTOKINE, MELLITUS, MARKERS, LESIONS

Abstract

Background. Monocyte chemoattractant protein (MCP)-1 is suggested to be implicated in the pathogenesis of diabetic nephropathy by activating and recruiting monocytes to the glomerulus via regulation of adhesion molecule expressions. The aim of this study was to test potential associations between serum concentrations of MCP-1, monocyte expression of Mac-1 and LFA-1 and nephropathy in type 1 diabetes mellitus.