Serum monocyte chemoattractant protein-1 and monocyte adhesion molecules in type 1 diabetic patients with nephropathy

Kiyici, Sinem; Erturk, Erdinc; Budak, FERAH; Ersoy, Canan; Tuncel, Ercan; Duran, Cevdet; Oral, HALUK; Sigirci, Deniz; Imamoglu, Sazi

doi:10.1016/j.arcmed.2006.06.002

Serum monocyte chemoattractant protein-1 and monocyte adhesion molecules in type 1 diabetic patients with nephropathy

Kiyici S., Erturk E., Budak F. , Ersoy C., Tuncel E., Duran C., ...More

ARCHIVES OF MEDICAL RESEARCH, vol.37, no.8, pp.998-1003, 2006 (Journal Indexed in SCI)

Publication Type: Article / Article
Volume: 37 Issue: 8
Publication Date: 2006
Doi Number: 10.1016/j.arcmed.2006.06.002
Title of Journal : ARCHIVES OF MEDICAL RESEARCH
Page Numbers: pp.998-1003
Keywords: diabetic nephropathy, MCP-1, adhesion molecules, ENDOTHELIAL DYSFUNCTION, EXPRESSION, RECRUITMENT, MACROPHAGES, ACTIVATION, CHEMOKINES, CYTOKINE, MELLITUS, MARKERS, LESIONS

Abstract

Background. Monocyte chemoattractant protein (MCP)-1 is suggested to be implicated in the pathogenesis of diabetic nephropathy by activating and recruiting monocytes to the glomerulus via regulation of adhesion molecule expressions. The aim of this study was to test potential associations between serum concentrations of MCP-1, monocyte expression of Mac-1 and LFA-1 and nephropathy in type 1 diabetes mellitus.