Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?

Kaya H., Desdicioglu R., SEZİK M., Ulukaya E., Ozkaya O., Yimaztepe A., ...More

FERTILITY AND STERILITY, vol.89, no.3, pp.732-735, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Editorial Material
  • Volume: 89 Issue: 3
  • Publication Date: 2008
  • Doi Number: 10.1016/j.fertnstert.2007.03.065
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.732-735
  • Bursa Uludag University Affiliated: Yes


The aim of this study was to assess the possible protective effect of sphingosine-1-phosphate (S1P), a polar sphingoid metabolite that seemingly promotes cell survival, on cytotoxin- and irradiation-induced ovarian injury in the rat model. Administration of S I P into ovarian bursa before whole-body irradiation led to decreased percentage of apoptotic cells, mostly in primordial follicles; however, S1P was not effective against apoptosis in rats that were given intraperitoneal cyclophosphamide.