Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?

Kaya H., Desdicioglu R., SEZİK M., Ulukaya E., Ozkaya O., Yimaztepe A., ...Daha Fazla

FERTILITY AND STERILITY, cilt.89, sa.3, ss.732-735, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Editöre Mektup
  • Cilt numarası: 89 Sayı: 3
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1016/j.fertnstert.2007.03.065
  • Dergi Adı: FERTILITY AND STERILITY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.732-735
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

The aim of this study was to assess the possible protective effect of sphingosine-1-phosphate (S1P), a polar sphingoid metabolite that seemingly promotes cell survival, on cytotoxin- and irradiation-induced ovarian injury in the rat model. Administration of S I P into ovarian bursa before whole-body irradiation led to decreased percentage of apoptotic cells, mostly in primordial follicles; however, S1P was not effective against apoptosis in rats that were given intraperitoneal cyclophosphamide.