Does sphingosine-1-phosphate have a protective effect on cyclophosphamide- and irradiation-induced ovarian damage in the rat model?
FERTILITY AND STERILITY, vol.89, no.3, pp.732-735, 2008 (SCI-Expanded, Scopus)
- Publication Type: Article / Editorial Material
- Volume: 89 Issue: 3
- Publication Date: 2008
- Doi Number: 10.1016/j.fertnstert.2007.03.065
- Journal Name: FERTILITY AND STERILITY
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.732-735
- Bursa Uludag University Affiliated: Yes
Abstract
The aim of this study was to assess the possible protective effect of sphingosine-1-phosphate (S1P), a polar sphingoid metabolite that seemingly promotes cell survival, on cytotoxin- and irradiation-induced ovarian injury in the rat model. Administration of S I P into ovarian bursa before whole-body irradiation led to decreased percentage of apoptotic cells, mostly in primordial follicles; however, S1P was not effective against apoptosis in rats that were given intraperitoneal cyclophosphamide.