Serum leptin concentration is increased in patients with Behcet's syndrome and is correlated with disease activity

EVEREKLİOĞLU C., Inaloz H., Kirtak N., Doganay S., Bulbul M., OTLU B., ...More

BRITISH JOURNAL OF DERMATOLOGY, vol.147, no.2, pp.331-336, 2002 (SCI-Expanded) identifier identifier identifier


Background Behcet's syndrome is a systemic, relapsing immuno-inflammatory disease with a generalized vasculitis of the microvasculature endothelial dysfunction. Leptin, a recently discovered neuroendocrine hormone, is a metabolic peptide that appears to be involved. Serum proinflammatory cytokines upregulate leptin levels and leptin itself directly induces nitric oxide production from endothelial cells with its specific receptors.