Serum leptin concentration is increased in patients with Behcet's syndrome and is correlated with disease activity


EVEREKLİOĞLU C., Inaloz H., Kirtak N., Doganay S. , Bulbul M., OTLU B., ...More

BRITISH JOURNAL OF DERMATOLOGY, vol.147, no.2, pp.331-336, 2002 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 147 Issue: 2
  • Publication Date: 2002
  • Doi Number: 10.1046/j.1365-2133.2002.04703.x
  • Title of Journal : BRITISH JOURNAL OF DERMATOLOGY
  • Page Numbers: pp.331-336

Abstract

Background Behcet's syndrome is a systemic, relapsing immuno-inflammatory disease with a generalized vasculitis of the microvasculature endothelial dysfunction. Leptin, a recently discovered neuroendocrine hormone, is a metabolic peptide that appears to be involved. Serum proinflammatory cytokines upregulate leptin levels and leptin itself directly induces nitric oxide production from endothelial cells with its specific receptors.