Effects of Origanum onites on endothelial function and serum biochemical markers in hyperlipidaemic patients

Ozdemir B., Ekbul A., Topal N. B., Sarandol E., Sag S., Baser K. H. C., ...Daha Fazla

Journal of International Medical Research, cilt.36, sa.6, ss.1326-1334, 2008 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 36 Sayı: 6
  • Basım Tarihi: 2008
  • Doi Numarası: 10.1177/147323000803600621
  • Dergi Adı: Journal of International Medical Research
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1326-1334
  • Anahtar Kelimeler: HYPERLIPIDAEMIA, ORIGANUM ONITES, THYME, ARTERIAL FUNCTION, FLOW-MEDIATED DILATION, DENSITY-LIPOPROTEIN, BIOLOGICAL-ACTIVITY, OXIDATIVE STRESS, ESSENTIAL OILS, HEART-DISEASE, LIPID PROFILE, RISK-FACTORS, OLIVE OIL, RED WINE, PARAOXONASE
  • Bursa Uludağ Üniversitesi Adresli: Evet

Özet

The effects of Origanum onites on endothelial function and antioxidative status were investigated in 48 patients with mild hyperlipidaemia who required no drug therapy. All participants were given lifestyle and low-fat dietary advice, however 32 of the patients (study group) were also prescibed 25 ml of aqueous distlllate of Origanum onites to be taken after each meal for 3 months. The remaining 16 patients were the control group. Various biochemical markers and endothelial function parameters were measured at baseline and after 3 months. A significantly greater increase in high density lipoprotein-cholesterol and significantly greater decreases in low density lipoprotein-cholesterol, apolipo-protein B, lipoprotein(a) and high-sensitivity C-reactive protein occurred in the study group compared with the control group over the 3-month study period. Paraoxonase and arylesterase activities, and flow- and nitroglycerine-mediated dilatation of the brachial artery showed significantly greater increases in the study group compared with the changes in the control group. In conclusion, consumption of Origanum onites distallate had beneficial effects on lipid profiles, antioxidant status and endothelial function in patients with mild hyperlipidaemia. Copyright © 2008 Field House Publishing LLP.