Effects of Origanum onites on endothelial function and serum biochemical markers in hyperlipidaemic patients

Ozdemir B., Ekbul A., Topal N. B., Sarandol E., Sag S., Baser K. H. C., ...More

Journal of International Medical Research, vol.36, no.6, pp.1326-1334, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 6
  • Publication Date: 2008
  • Doi Number: 10.1177/147323000803600621
  • Journal Name: Journal of International Medical Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1326-1334
  • Keywords: HYPERLIPIDAEMIA, ORIGANUM ONITES, THYME, ARTERIAL FUNCTION, FLOW-MEDIATED DILATION, DENSITY-LIPOPROTEIN, BIOLOGICAL-ACTIVITY, OXIDATIVE STRESS, ESSENTIAL OILS, HEART-DISEASE, LIPID PROFILE, RISK-FACTORS, OLIVE OIL, RED WINE, PARAOXONASE
  • Bursa Uludag University Affiliated: Yes

Abstract

The effects of Origanum onites on endothelial function and antioxidative status were investigated in 48 patients with mild hyperlipidaemia who required no drug therapy. All participants were given lifestyle and low-fat dietary advice, however 32 of the patients (study group) were also prescibed 25 ml of aqueous distlllate of Origanum onites to be taken after each meal for 3 months. The remaining 16 patients were the control group. Various biochemical markers and endothelial function parameters were measured at baseline and after 3 months. A significantly greater increase in high density lipoprotein-cholesterol and significantly greater decreases in low density lipoprotein-cholesterol, apolipo-protein B, lipoprotein(a) and high-sensitivity C-reactive protein occurred in the study group compared with the control group over the 3-month study period. Paraoxonase and arylesterase activities, and flow- and nitroglycerine-mediated dilatation of the brachial artery showed significantly greater increases in the study group compared with the changes in the control group. In conclusion, consumption of Origanum onites distallate had beneficial effects on lipid profiles, antioxidant status and endothelial function in patients with mild hyperlipidaemia. Copyright © 2008 Field House Publishing LLP.