A new hepatitis B virus vaccine escape mutation in a renal transplant recipient


Sayiner A. A. , Agca H., Sengonul A., Celik A., Akarsu M.

JOURNAL OF CLINICAL VIROLOGY, vol.38, no.2, pp.157-160, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 2
  • Publication Date: 2007
  • Doi Number: 10.1016/j.jcv.2006.12.002
  • Journal Name: JOURNAL OF CLINICAL VIROLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.157-160
  • Keywords: hepatitis B virus, HBV, HBsAg, vaccine escape mutant, SURFACE-ANTIGEN VARIANTS, MUTANT DETECTION, HBSAG ASSAYS, SENSITIVITY, INFECTION
  • Bursa Uludag University Affiliated: Yes

Abstract

Surface antigen mutations of hepatitis B virus (HBV) may lead to immune escape and cause failure of immunization. In this report, the development of a chronic HBV infection in a vaccinated renal transplant recipient with pre-existing anti-HBs antibody is documented. The sequencing data showed that the HBV strain carried five amino acid substitutions in the major hydrophilic region of the S protein, one (sS143L) located at the "a" determinant. A commercial HBsAg assay failed to detect the mutant antigen. (C) 2006 Elsevier B.V. All rights reserved.