Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting

Isler, Burcu; Ozer, Berna; Çinar, Güle; Aslan, Abdullah; Vatansever, Cansel; Falconer, Caitlin; Dolapci, Istar; Simsek, Funda; Tülek, Necla; Demirkaya, Hamiyet; Menekse, Sirin; Akalin, EMİN; Balkan, Ilker; Aydin, Mehtap; Tigen, Elif; Demir, Safiye; Kapmaz, Mahir; Keske, Siran; Dogan, Ozlem; Arabaci, Cigdem; Yagci, Serap; Hazirolan, Gülşen; Bakir, Veli; Gonen, Mehmet; Chatfield, Mark; Forde, Brian; Saltoğlu, Neşe; Azap, Alpay; Azap, Özlem; Akova, Murat; Paterson, David; Can, Fusun; Ergonul, Onder

doi:10.1007/s10096-022-04425-4

Characteristics and outcomes of carbapenemase harbouring carbapenem-resistant Klebsiella spp. bloodstream infections: a multicentre prospective cohort study in an OXA-48 endemic setting

Isler B., Ozer B., Çinar G., Aslan A. T., Vatansever C., Falconer C., ...Daha Fazla

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, cilt.41, sa.5, ss.841-847, 2022 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 41 Sayı: 5
Basım Tarihi: 2022
Doi Numarası: 10.1007/s10096-022-04425-4
Dergi Adı: EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, PASCAL, Agricultural & Environmental Science Database, CAB Abstracts, EMBASE, Environment Index, MEDLINE, Public Affairs Index, Veterinary Science Database
Sayfa Sayıları: ss.841-847
Anahtar Kelimeler: OXA-48, OXA-232, ST2096, Klebsiella pneumoniae, Ceftazidime-avibactam, PNEUMONIAE, OXA-232, ENTEROBACTERALES, COPRODUCTION, SPREAD, NDM-1
Bursa Uludağ Üniversitesi Adresli: Evet

Özet

A prospective, multicentre observational cohort study of carbapenem-resistant Klebsiella spp. (CRK) bloodstream infections was conducted in Turkey from June 2018 to June 2019. One hundred eighty-seven patients were recruited. Single OXA-48-like carbapenemases predominated (75%), followed by OXA-48-like/NDM coproducers (16%). OXA-232 constituted 31% of all OXA-48-like carbapenemases and was mainly carried on ST2096. Thirty-day mortality was 44% overall and 51% for ST2096. In the multivariate cox regression analysis, SOFA score and immunosuppression were significant predictors of 30-day mortality and ST2096 had a non-significant effect. All OXA-48-like producers remained susceptible to ceftazidime-avibactam.